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Dr Ruoyu Miao
Fellow

Dr Ruoyu Miao

Bye Fellow; Senior Data Scientist, Wellcome Sanger Institute

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Biography

Dr Ruoyu Miao is a Senior Postdoctoral Fellow at the Wellcome Sanger Institute, jointly affiliated with the University of Cambridge. Her research lies at the intersection of biostatistics, machine learning and computational biology, with a particular focus on women’s health, diabetes and precision medicine. She develops innovative statistical and computational methods to integrate complex biomedical datasets, including proteomics, metabolomics and spatial transcriptomics, to uncover disease mechanisms, identify clinically relevant biomarkers and improve early disease prediction. Her research has contributed to advancing the understanding and early prediction of pregnancy complications. Her work on Isthmin-2, published in , demonstrated its essential role in extravillous trophoblast invasion and its potential as a first-trimester predictor of pre-eclampsia and fetal growth restriction. The research was also featured in  and highlighted by the . With patent applications and technology licensing supporting its translational potential, this work exemplifies her commitment to translating statistical and computational discoveries into meaningful clinical applications. Alongside her research, Dr Miao is committed to teaching, mentoring and interdisciplinary collaboration. She is an Associate Fellow of Advance HE (AFHEA) and has experience in statistics teaching, student supervision and individual mentoring. Her international academic engagement includes chairing sessions at EcoSta. She also contributes to peer review, interdisciplinary research collaboration and public engagement, sharing scientific knowledge with a broad audience.

Specific Research Interests

Statistical and computational methods for integrating proteomic, metabolomic and spatial transcriptomic data; women's health and pregnancy complications; diabetes; biomarker discovery; early disease prediction and precision medicine.

Degrees

PhD in Statistics, University of Manchester

Honours

Associate Fellow of Advance HE (AFHEA)

Major Awards and Prizes

School Scholarship for doctoral research in Statistics, University of Manchester

Authored work

  • Miao, R., Gong, S., Sovio, U., et al. (2026). Isthmin-2 is a first-trimester predictor of preeclampsia and fetal growth restriction. Nature Medicine, 32, 3351–3358. Published 1 September 2026. DOI: https://doi.org/10.1038/s41591-026-04573-6